Parameter

Healthy S              BS

Infected S             BS

LSD (Pr > F)

C˚ (μg∙ml⁻¹)

6.47 (0.38)^c

7.43 (0.12)^a

6.96 (0.14)^b

7.47 (0.24)^a

0.323 (0.0001)

A (μg∙ml⁻¹)

5.27 (0.29)^c

6.12 (0.10)^a

5.81 (0.07)^b

5.79 (0.16)^b

0.234 (0.0001)

α (h⁻⁴)

0.71 (0.03)^a

0.64 (0.02)^b

0.70 (0.02)^a

0.56 (0.01)^c

0.026 (0.0001)

t_1/2(a) (h)

2.70 (0.10)^c

2.99 (0.07)^b

2.76 (0.09)^c

3.49 (0.05)^a

0.105 (0.0001)

B (μg∙ml⁻¹)

1.20 (0.12)^bc

1.29 (0.07)^b

1.15 (0.08)^c

1.69 (0.09)^a

0.122 (0.0001)

b (h⁻²)

0.32 (0.03)^a

0.32 (0.01)^a

0.32 (0.02)^a

0.34 (0.01)^a

0.025 (0.2311)

t_1/2(b) (h)

22.09 (1.96)^a

21.72 (0.99)^a

22.14 (1.10)^a

20.53 (0.33)^a

1.658 (0.1821)

V_c (Litre∙kg⁻¹)

1.55 (0.09)^a

1.35 (0.02)^c

1.44 (0.03)^b

1.34 (0.04)^c

0.071 (0.0001)

V_d(area) (Litre∙kg⁻¹)

4.28 (0.12)^a

3.29 (0.08)^c

3.83 (0.06)^b

2.84 (0.10)^d

0.124 (0.0001)

V_d(ss) (Litre∙kg⁻¹)

1.90 (0.09)^a

1.63 (0.02)^c

1.72 (0.02)^b

1.72 (0.05)^b

0.090 (0.0001)

Cl_(B) (Litre∙kg⁻¹∙h⁻¹)

0.14 (0.01)^a

0.11 (0.004)^c

0.12 (0.01)^b

0.10 (0.003)^d

0.009 (0.0001)

AUC (μg∙h⁻¹∙Litre⁻¹)

73.95 (6.18)^d

95.19 (3.66)^b

83.50 (3.43)^c

104.35 (2.76)^a

5.643 (0.0001)

AUMC (μg∙h⁻¹∙Litre⁻¹)

155.1 (44.01)^a

185.1 (51.78)^a

169.6 (32.65)^a

202.0 (18.53)^a

52.04 (0.2934)

AUMC_inf (μg∙h⁻¹∙Litre⁻¹)

2941 (240.17)^a

2118 (525.58)^bc

2525 (186.16)^ab

1860 (189.82)^c

427.5 (0.0004)

MRT (h)

2.25 (0.44)^a

2.11 (0.49)^a

2.20 (0.33)^a

2.11 (0.18)^a

0.508 (0.9107)

MRT_inf (h)

25.27 (1.45)^a

26.60 (4.72)^a

25.46 (1.41)^a

28.36 (1.48)^a

3.58 (0.2752)